Trehalose synthase of Mycobacterium smegmatis
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چکیده
منابع مشابه
Trehalose synthase of Mycobacterium smegmatis
Yuan T. Pan, Vineetha Koroth Edavana, William J. Jourdian, Rick Edmondson, J. David Carroll, Irena Pastuszak and Alan D. Elbein Department of Biochemistry and Molecular Biology and Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, AR, USA; Departments of Biological Chemistry and Internal Medicine, University of Michigan Medical Center, Ann Arbo...
متن کاملMechanistic analysis of trehalose synthase from Mycobacterium smegmatis.
Trehalose synthase (TreS) catalyzes the reversible interconversion of maltose and trehalose and has been shown recently to function primarily in the mobilization of trehalose as a glycogen precursor. Consequently, the mechanism of this intriguing isomerase is of both academic and potential pharmacological interest. TreS catalyzes the hydrolytic cleavage of α-aryl glucosides as well as α-glucosy...
متن کاملTrehalose Is Required for Growth of Mycobacterium smegmatis*□S
Mycobacteria contain high levels of the disaccharide trehalose in free form as well as within various immunologically relevant glycolipids such as cord factor and sulfolipid-1. By contrast, most bacteria use trehalose solely as a general osmoprotectant or thermoprotectant. Mycobacterium tuberculosis and Mycobacterium smegmatis possess three pathways for the synthesis of trehalose. Most bacteria...
متن کاملTrehalose is required for growth of Mycobacterium smegmatis.
Mycobacteria contain high levels of the disaccharide trehalose in free form as well as within various immunologically relevant glycolipids such as cord factor and sulfolipid-1. By contrast, most bacteria use trehalose solely as a general osmoprotectant or thermoprotectant. Mycobacterium tuberculosis and Mycobacterium smegmatis possess three pathways for the synthesis of trehalose. Most bacteria...
متن کاملMICROBIAL TRANSFORMATION OF CHOLESTEROL BY MYCOBACTERIUM SMEGMATIS
Mycobacterium smegmatis PTCC 1307 (CIP 73.26) was used as a microbial agent to produce androsta-1,4-diene-3,17-dione (ADD) and androst-4-ene-3,17-dione, two useful precursors in the synthesis of steroid drugs. The side chain of cholesterol, as the substrate, was selectively cleaved in the presence of five enzyme inhibitors. An intermediate structure with intact side chain, cholest-4-ene-3-one, ...
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ژورنال
عنوان ژورنال: European Journal of Biochemistry
سال: 2004
ISSN: 0014-2956,1432-1033
DOI: 10.1111/j.1432-1033.2004.04365.x